Dr. Moffat joined the Donnelly Centre in 2007 after a postdoctoral fellowship at the Whitehead and Broad Institutes where he helped to develop the first lentiviral RNA interference libraries for systematic perturbation of all human and mouse genes. The Moffat lab is broadly interested in the regulation of cell growth and proliferation in cancer cells and has been developing genetic tools to identify genes encoding cancer cell surface proteins important for cellular fitness and cellular state. Together with the Sidhu lab, the Moffat lab is also developing new methods and technologies for the identification of synthetic antibody reagents against cell surface molecules that could be used as research tools for exploring protein structure and function.


Dr. Frederic Fellouse, researcher affiliated with Dr. Sachdev Sidhu’s laboratory at the University of Toronto, has a pharmacy and bioengineering background. His PhD work conducted at Genentech and the University of Provence, allowed the development of highly functional synthetic antibody repertoires surpassing the functionality of the natural immune system. This new generation of biologics enables quick and low-cost discovery of high performance reagents, therapeutics and diagnostics. As a postdoctoral fellow at the Lunenfeld Research Institute in Professor Wrana and Pawson, Dr. Fellouse developed synthetic antibodies as reagents to explore cell signaling. Dr. Fellouse now leads a protein engineering research program as well as the development of therapeutic and diagnostic antibodies to treat cancer, eye diseases and infectious diseases. In the area of infectious diseases, Dr. Fellouse’s current interests are around Dengue fever treatments and diagnostics and the improvement of a vaccine for cattle East Coast fever.